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Name:Thomas Vosegaard
Profession:Associate Professor
Email:
Homepage:www.chem.au.dk/~tv
Work address: Laboratory for Biomolecular NMR Spectroscopy
Department of Chemistry
University of Aarhus
Langelandsgade 140, DK-8000 Aarhus C, Denmark
Home address: Flintebakken 208
DK-8240 Risskov
Denmark
Office: Room 512-214
Office phone: +45 8942 3866
Dept. duties: Computer system administrator, web master

Research

My research interest at the laboratory for biomolecular NMR spectroscopy is centered around numerical and experimental aspects of solid-state NMR investigations of membrane proteins in uni-axially oriented bilayers.
 

Curriculum Vitae


Personal data

Name:Thomas Vosegaard
Nationality:Danish
Date of Birth:November 24, 1970
Marital status:Married, father of Emilie, Lasse, and Benedicte


Education

1996:M.Sc., Chemistry and Physics, University of Aarhus
1998:Ph.D., Solid-State NMR Spectroscopy, University of Aarhus


Appointments

1989-1990:Machine Engineer
1990-1994:M.Sc. student
1994-1998:NF Ph.D. stipend
1998-1999:Research Assistant Professor, Instrument Centre for Solid-State NMR Spectroscopy, University of Aarhus
1999-2000:Carlsberg postdoctoral fellow, CNRS, Orléans, France
2000-:Assistant Professor, Laboratory for Biomolecular NMR Spectroscopy, University of Aarhus


Awards

1999:Ph.D. price from the Danish Academy of Natural Sciences


Academic work

1994-1996:Member of Board, Department of Chemistry, University of Aarhus

Publications

Publications in Reviewed Journals

  1. T. Vosegaard, J. Skibsted, H. Bildsøe, and H. J. Jakobsen, J. Phys. Chem. 99, 10731 (1995).
    Combined Effect of Second-Order Quadrupole Coupling and Chemical Shielding Anisotropy on the Central Transition in MAS NMR of Quadrupolar Nuclei. 87Rb MAS NMR of RbClO4
  2. T. Vosegaard, V. Langer, P. Daugaard, E. Hald, H. Bildsøe, and H. J. Jakobsen, Rev. Sci. Instrum. 67, 2130-2133 (1996).
    A New Goniometer Design for Single-Crystal Nuclear Magnetic Resonance Spectroscopy
  3. J. Skibsted, T. Vosegaard, H. Bildsøe, and H. J. Jakobsen, J. Phys. Chem. 100, 14872-14881 (1996).
    133Cs Chemical Shielding Anisotropies and Quadrupole Couplings from Magic-Angle Spinning NMR of Cesium Salts
  4. T. Vosegaard, J. Skibsted, H. Bildsøe, and H. J. Jakobsen, J. Magn. Reson. A 122, 111-119 (1996).
    Quadrupole Coupling and Anisotropic Shielding from Single-Crystal NMR of the Central Transition for Quadrupolar Nuclei. 87Rb NMR of RbClO4 and Rb2SO4
  5. T. Vosegaard, F. H. Larsen, H. J. Jakobsen, P. D. Ellis, and N. C. Nielsen, J. Am. Chem. Soc. 119, 9055-9056 (1997).
    Sensitivity-Enhanced Multiple-Quantum MAS NMR of Half-Integer Quadrupolar Nuclei
  6. T. Vosegaard, D. Massiot, N. Gautier, and H. J. Jakobsen, Inorg. Chem. 36, 2446-2450 (1997).
    71Ga Chemical Shielding and Quadrupole Coupling Tensors of the Garnet Y3Ga5O12 from Single-Crystal 71Ga NMR
  7. T. Vosegaard and H. J. Jakobsen, J. Magn. Reson. 128, 135-137 (1997).
    27Al Chemical Shielding Anisotropy
  8. Thomas Vosegaard, Inger P. Byriel, and Hans J. Jakobsen, J. Phys. Chem. B 101, 8955-8958 (1997).
    Characterization of the Two Rubidium Sites in Rb2CrO4 by 87Rb Single-Crystal NMR
  9. T. Vosegaard, E. Hald, V. Langer, H. J. Skov, P. Daugaard, H. Bildsøe, and H. J. Jakobsen, J. Magn. Reson. 135, 126-132 (1998).
    Improved Hardware and Software for Single-Crystal NMR Spectroscopy
  10. T. Vosegaard, I. P. Byriel, D. A. Pawlak, K. Wozniak, and H. J. Jakobsen, J. Am. Chem. Soc. 120, 7900-7904 (1998).
    Crystal Structure Studies on the Garnet Y3Al5O12 by 27Al Single-Crystal NMR Spectroscopy
  11. T. Vosegaard, I. P. Byriel, L. Binet, D. Massiot, and H. J. Jakobsen, J. Am. Chem. Soc. 120, 8184-8188 (1998).
    Crystal Structure Studies by Single-Crystal NMR Spectroscopy. 71Ga and 69Ga Single-Crystal NMR of β-Ga2O3 Twins
  12. T. Vosegaard, J. Skibsted, and H. J. Jakobsen, J. Phys. Chem. A 103, 9144-9149 (1999).
    Characterization of Mo(CO)6 by 95Mo Single-Crystal NMR Spectroscopy
  13. D. Massiot, T. Vosegaard, N. Magneron, D. Trumeau, V. Montouillout, P. Berthet, T. Loiseau, and B. Bujoli, Solid State Nucl. Magn. Reson. 15, 159-169 (1999).
    71Ga NMR of reference GaIV, GaV, and GaVI compounds by MAS and QPASS, extension of gallium/aluminum NMR parameter correlation
  14. T. Vosegaard, E. Hald, P. Daugaard, and H. J. Jakobsen, Rev. Sci. Instrum. 70, 1771-1779 (1999).
    A Two-Axis Goniometer for Sensitivity Enhancement in Single-Crystal NMR Spectroscopy
  15. T. Vosegaard, U. Andersen, and H. J. Jakobsen, J. Am. Chem. Soc. 121, 1970-1971 (1999).
    Improved 67Zn Solid-State NMR from Single-Crystal Studies. Zn(CH3COO)2·H2O
  16. T. Vosegaard, J. Skibsted, H. Bildsøe, and H. J. Jakobsen, Solid State Nucl. Magn. Reson. 14, 203-210 (1999).
    Solid-State 87Rb NMR of RbVO3. A Comparison of Experiments for Retrieving Chemical Shielding and Quadrupole Coupling Tensorial Interactions
  17. T. Vosegaard, D. Massiot, and P. J. Grandinetti, Chem. Phys. Lett. 326, 454-460 (2000).
    Sensitivity enhancements in MQ-MAS NMR of spin-5/2 nuclei using modulated rf mixing pulses
  18. T. Vosegaard, P. Florian, P. J. Grandinetti, and D. Massiot, J. Magn. Reson. 143, 217-222 (2000).
    Pure Absorption-Mode Spectra using a Modulated RF Mixing Period in MQMAS Experiments
  19. T. R. Jensen, R. G. Hazell, T. Vosegaard, and H. J. Jakobsen, Inorg. Chem. 39, 2026-2032 (2000).
    New Rubidium Zinc Hydrogen Phosphate, Rb2Zn2(HPO4)3: Synthesis, Crystal Structure, and 31P Single-Crystal NMR
  20. T. Vosegaard, E. Hald, P. Daugaard, and H. J. Jakobsen, J. Magn. Reson. 142, 379-381 (2000).
    Small Crystals and Small Coils in Variable Temperature Single-Crystal NMR
  21. T. Vosegaard, P. Florian, D. Massiot, and P. J. Grandinetti, J. Chem. Phys. 114, 4618-4624 (2001).
    Multiple Quantum Magic-Angle Spinning using Rotary Resonance Excitation
  22. T. Vosegaard, A. Malmendal, and N. C. Nielsen, Chem. Monthly 133, 1555-1574 (2002).
    The Flexibility of SIMPSON and SIMMOL for Numerical Simulations in Solid and Liquid-State NMR Spectroscopy
  23. M. Bak, R. Schultz, T. Vosegaard, and N. C. Nielsen, J. Magn. Reson. 154, 28-45 (2002).
    Specification and visualization of anisotropic interaction tensors in polypeptides and numerical simulations in biological solid-state NMR
  24. T. Vosegaard and N. C. Nielsen, J. Biomol. NMR 22, 225-247 (2002).
    Towards high-resolution solid-state NMR on large uniformly 15N- and [13C,15N]-labeled membrane proteins in oriented lipid bilayers
  25. A. Goldbach, F. Fayon, T. Vosegaard, M. Wachhold, M. G. Kanatzidis, D. Massiot, and M.-L. Saboungi, Inorg. Chem. 42, 6996-7000 (2003).
    77Se and 87Rb Solid State NMR Study of the Structure of Rb2[Pd(Se4)2]·Se8
  26. M. Bjerring, T. Vosegaard, A. Malmendal, and N. C. Nielsen, Concepts Magn. Reson. 18A, 111-129 (2003).
    Methodological Development of Solid-State NMR for Characterization of Membrane Proteins
  27. M. R. Hansen, T. Vosegaard, H. J. Jakobsen, and J. Skibsted, J. Phys. Chem. A 108, 586-594 (2004).
    11B Chemical Shift Anisotropies in Borates from 11B MAS, MQMAS, and Single-Crystal NMR Spectroscopy
  28. N.C. Nielsen, A. Malmendal, and T. Vosegaard, Mol. Membr. Biol. 21, 129-141 (2004).
    Techniques and Applications of NMR to Membrane Proteins
  29. T. Vosegaard and N. C. Nielsen, Magn. Reson. Chem. 42, 285-290 (2004).
    Improved pulse sequences for pure exchange solid-state NMR spectroscopy
  30. T. Vosegaard, C. T. Kehlet, N. Khaneja, S. J. Glaser, and N. C. Nielsen, J. Am. Chem. Soc. 127, 13768-13769 (2005).
    Improved excitation schemes for multiple-quantum magic-angle spinning for quadrupolar nuclei designed using optimal control theory
  31. C. T. Kehlet, T. Vosegaard, N. Khaneja, S. J. Glaser, and N. C. Nielsen, Chem. Phys. Lett. 414, 204-209 (2005).
    Low-power homonuclear dipolar recoupling in solid-state NMR developed using optimal control theory
  32. M. Kamihira, T. Vosegaard, A. J. Mason, S. Straus, N. C. Nielsen, and A. Watts, J. Struct. Biol. 149, 7-16 (2005).
    Structural and orientational constraints of bacteriorhodopsin in purple membranes determined by oriented-sample solid-state NMR spectroscopy
  33. A.C. Sivertsen, M. Bjerring, C.T. Kehlet, T. Vosegaard, N.C. Nielsen, Annu. Rep. NMR Spectrosc. 54, 243-293 (2005).
    Numerical Simulations in Biological Solid-State NMR Spectroscopy
  34. K. Bertelsen, J. M. Pedersen, N. C. Nielsen, and T. Vosegaard, J. Magn. Reson. 184, 273-279 (2007).
    2D separated-local field spectra from projections of 1D experiments
  35. T. Vosegaard and D. Massiot, Chem. Phys. Lett. 437, 120-125 (2007).
    High-resolution two-dimensional NMR spectra of half-integer-spin quadrupolar nuclei from one-dimensional projections
  36. J. Ø. Hansen, C. Kehlet, M. Bjerring, T. Vosegaard, S. J. Glaser, N. Khaneja, and N. C. Nielsen, Chem. Phys. Lett. 447, 154-161 (2007).
    Optimal control based design of composite dipolar recoupling experiments by analogy to single-spin inversion pulses
  37. K. Bertelsen, J. M. Pedersen, B. S. Rasmussen, T. Skrydstrup, N. C. Nielsen, and T. Vosegaard, J. Am. Chem. Soc. 129, 14717-14723 (2007).
    Membrane-Bound Conformation of Peptaibols with Methyl-Deuterated a-Amino Isobutyric Acids by 2H MAS Solid-State NMR Spectroscopy
  38. T. Vosegaard, M. Kamihira-Ishijima, A. Watts, and N. C. Nielsen, Biophys. J. 94, 241-250 (2008).
    Helix conformations in 7TM membrane proteins determined using oriented-sample solid-state NMR with multiple residue specific 15N labeling
  39. T. Vosegaard, K. Bertelsen, J. M. Pedersen, L. Thøgersen, B. Schiøtt, E. Tajkhorshid, T. Skrydstrup, and N. C. Nielsen, J. Am. Chem. Soc. 130, 5028-5029 (2008).
    Resolution Enhancement in Solid-State NMR of Oriented Membrane Proteins by Anisotropic Differential Linebroadening
  40. L. Thøgersen, B. Schiøtt, T. Vosegaard, N. C. Nielsen, and E. Tajkhorshid, Biophys. J. 95, 4337-4347 (2008).
    Peptide Aggregation and Pore Formation in a Lipid Bilayer - A Combined Coarse Grained and All Atom Molecular Dynamics Study
  41. C. U. Hjørringgaard, J. M. Pedersen, T. Vosegaard, N. C. Nielsen, and T. Skrydstrup, J. Org. Chem. 74, 1329-1332 (2009).
    An Automatic Solid Phase Synthesis of Peptaibols
  42. J. T. Nielsen, M. Bjerring, M. D. Jeppesen, R. O. Pedersen, J. M. Pedersen, K. L. Hein, T. Vosegaard, T. Skrydstrup, D. E. Otzen, and N. C. Nielsen, Angew. Chem. Intl. Ed. 48, 2118-2121 (2009).
    Unique identification of supramolecular structures in amyloid fibrils by solid-state NMR spectroscopy
  43. Z. Tosner, T. Vosegaard, C. T. Kehlet, N. Khaneja, S. Glaser, and N. C. Nielsen, J. Magn. Reson. 197, 120-134 (2009).
    Optimal Control in NMR Spectroscopy: Numerical implementation in SIMPSON
  44. J. Dittmer, L. Thøgersen, J. Underhaug, K. Bertelsen, T. Vosegaard, J. M. Pedersen, B. Schiøtt, E. Tajkhorshid, T. Skrydstrup, and N. C. Nielsen, J. Phys. Chem. B 113, 6928-2937 (2009).
    Incorporation of Antimicrobial Peptides into Membranes: A Combined Liquid-State NMR and Molecular Dynamics Study of Alamethicin in DMPC/DHPC Bicelles
  45. T. Vosegaard and N. C. Nielsen, J. Magn. Reson. 199, 146-158 (2009).
    Defining the sampling space in multidimensional NMR experiments: What should the maximum sampling time be?
  46. K. Bertelsen, B. Paaske, L. Thøgersen, E. Tajkhorshid, B. Schiøtt, T. Skrydstrup, N. C. Nielsen, and T. Vosegaard, J. Am. Chem. Soc. 131, 18335-18342 (2009).
    Residue-Specific Information about the Dynamics of Antimicrobial Peptides from 1H-15N and 2H Solid-State NMR Spectroscopy
  47. S. Jespersen, C. R. Bjarkam,, J. R. Nyengaard, M. M. Chakravarty, B. Hansen, T. Vosegaard, L. Østergaard, D. Yablonskiy, and N. C. Nielsen and P. Vestergaard-Poulsen, NeuroImage 49, 205-216 (2010).
    Neurite density from magnetic resonance diffusion measurements at ultrahigh field: comparison with light microscopy and electron microscopy
  48. B. S. Vad, L. A. Thomsen, K. Bertelsen, M. Franzmann, J. M. Pedersen, S. B. Nielsen, T. Vosegaard, Z. Valnickova, T. Skrydstrup, J. J. Enghild, R. Wimmer, N. C. Nielsen, and D. E. Otzen, Biochim. Biophys. Acta 1804, 806-820 (2010).
    Divorcing Folding from Function: How Acylation Affects the Membrane-perturbing Properties of an Anti-microbial Peptide
  49. T. Vosegaard, Z. Tosner, and N.C. Nielsen, Encyclopedia of Magnetic Resonance, eds. R. K. Harris and R. E. Wasylishen , (2010).
    Numerical Simulations in Solid-State NMR with SIMPSON
  50. T. Vosegaard, Solid State Nucl. Magn. Reson. 38, 77-83 (2010).
    Challenges in Numerical Simulations of Solid-State NMR Experiments: Spin Exchange Pulse Sequences
  51. K. Bertelsen, B. Vad, E. H. Nielsen, S. K. Hansen, T. Skrydstrup, D. E. Otzen, T. Vosegaard, and N. C. Nielsen, J. Phys. Chem. B 115, 1767-1774 (2011).
    Long-Term-Stable Ether-Lipid vs Conventional Ester- Lipid Bicelles in Oriented Solid-State NMR: Altered Structural Information in Studies of Antimicrobial Peptides
  52. C. Hjørringgaard, B. Vad, V. Matchkov, S. Nielsen, T. Vosegaard, N. C. Nielsen, D. Otzen, and T. Skrydstrup , J. Phys. Chem. B 116, 7652-7659 (2012).
    Cyclodextrin-Scaffolded Alamethicin with Remarkably Efficient Membrane Permeabilizing Properties and Membrane Current Conductance
  53. K. Bertelsen, J. Dorosz, S. K. Hansen, N. C. Nielsen, and T. Vosegaard, PLOS ONE 7, e47745 (2012).
    Mechanisms of Peptide-Induced Pore Formation in Lipid Bilayers Investigated by Oriented 31P Solid-State NMR Spectroscopy
  54. N. M. Balsgart and T. Vosegaard, J. Magn. Reson. 223, 164-169 (2012).
    Fast Forward Maximum Entropy Reconstruction of Sparsely Sampled Data

Theses and Reports

  1. Thomas Vosegaard, Ph.D. Thesis.
    Instrument Centre for Solid-State NMR Spectroscopy, University of Aarhus (1998).
    "Single-Crystal NMR Spectroscopy: Development of Instrumentation and Studies of Quadrupolar Nuclei"
  2. Thomas Vosegaard, Progress Report.
    Instrument Centre for Solid-State NMR Spectroscopy, University of Aarhus (1996).
    "Quadrupole Couplings and Chemical Shieldings from Single-Crystal and Magic-Angle Spinning NMR"

Seminar presentations

  1. Thomas Vosegaard,
    3rd Alpine Conference on Solid-State NMR, Chamonix, France (September 2003).
    "Structural and orientational constraints on Bacteriorhodopsin in purple membranes determined by oriented-sample solid-state NMR"
  2. Thomas Vosegaard,
    1st annual Meeting, Department of Molecular Biology (June 2003).
    "Solid-State NMR on Membrane Proteins"
  3. Thomas Vosegaard and Niels Chr. Nielsen,
    German-Scandinavian GDCh meeting on Magnetic Resonance and Molecular Interactions (September 2002).
    "Prospects for solid-state NMR on large uniformly labeled membrane proteins in oriented lipid bilayers"
  4. Thomas Vosegaard, Robert Schultz, Jimmy T. Rasmussen, Mads Bak, and Niels Chr. Nielsen,
    44th Rocky Mountain Conference on Analytical Chemistry, Denver, CO (July 2002).
    "SIMPSON and SIMMOL: A Flexible Vehicle for Numerical Simulations in Biomolecular Solid-State NMR"
  5. Thomas Vosegaard and Niels Chr. Nielsen,
    13th Annual Varian Workshop on Solid-State NMR, Estes Park, CO (August 2002).
    "The Flexibility of SIMPSON and SIMMOL for Numerical Simulations in Solid- and Liquid-State NMR Spectroscopy"
  6. Thomas Vosegaard, Mads Bak, Robert Schultz, and Niels Chr. Nielsen,
    University of California at San Diego (March 2001).
    "Novel Approaches to Sensitivity Enhanced MQ-MAS NMR of Half-Integer Quadrupoles"
  7. Thomas Vosegaard, Philip J. Grandinetti, Pierre Florian, and Dominique Massiot,
    Bruker: 3ème Réunion Utilizateurs RMN du Solide, Lyon, France (June 2000).
    "High Resolution and Sensitivity for Half-Integer Quadrupolar Nuclei"
  8. Thomas Vosegaard and Hans J. Jakobsen,
    Scandinavian NMR Symposium, Copenhagen, Denmark (May 1997).
    "Advances in Single-Crystal NMR"
  9. Thomas Vosegaard and Hans J. Jakobsen,
    Varian User's Meeting, Orlando, FL (February 1997).
    "Single-Crystal NMR of Quadrupolar Nuclei"
  10. Thomas Vosegaard, Jørgen Skibsted, Henrik Bildsøe, and Hans J. Jakobsen,
    18. Diskussionstagung, Fachgruppe Magnetische Resonanzspektroskopie, Eichstatt, Germany (September 1996).
    "Single-Crystal, MAS, and Static-Powder NMR Techniques in Studies of CSA and Quadrupole Coupling Interactions for Half-Integer Quadrupoles"
  11. Thomas Vosegaard, Jørgen Skibsted, Henrik Bildsøe, and Hans J. Jakobsen,
    13th European Experimental NMR Conference, Paris (May 1996).
    "Quadrupole Coupling and Anisotropic Shielding from Single-Crystal NMR of the Central Transition for Quadrupolar Nuclei Employing a New Goniometer Design"

Poster presentations

  1. Thomas Vosegaard, Miya Kamihira, James Mason, Suzana Strauss, Anthony Watts, and Niels Chr. Nielsen,
    45th Experimental NMR Conference, Asilomar, CA (April 2004).
    "Structural Constraints on Bacteriorhodopsin in Different States From Oriented-Sample Solid-State NMR Spectroscopy"
  2. Thomas Vosegaard, Morten Bjerring, Mads Bak, Miya Kamihira, James Mason, Suzana Strauss, Anthony Watts, and Niels Chr. Nielsen,
    1st Annual iNANO meeting (January 2003).
    "Solid-State NMR as a Tool for Determining Structures of Membrane Proteins"
  3. Thomas Vosegaard and Niels Chr. Nielsen,
    43rd Experimental NMR Conference, Asilomar, CA (March 2002).
    "Towards High-Resolution Solid-State NMR on Large Uniformly Labelled Membrane Proteins in Oriented Lipid Bilayers"
  4. Thomas Vosegaard, Mads Bak, Robert Schultz, and Niels Chr. Nielsen,
    42nd Experimental NMR Conference, Orlando, FL (March 2001).
    "SIMMOL: Specification and Visualization of Anisotropic Interactrion Tensors in Proteins"
  5. Thomas Vosegaard, Dominique Massiot, Philip J. Grandinetti,
    41st Experimental NMR Conference, Asilomar, CA (April 2000).
    "On the 3Q -> 1Q Mixing in MQ-MAS NMR"
  6. Thomas Vosegaard, Pierre Florian, Dominique Massiot, Philip J. Grandinetti,
    1st Alpine Conference on Solid-State NMR, Chamonix, France (September 1999).
    "Pure Absorption-Mode Spectra Using Modulated RF MQMAS Experiments"
  7. Thomas Vosegaard, Pierre Florian, Dominique Massiot, Philip J. Grandinetti,
    41st Rocky Mountain Conference, Denver, CO (August 1999).
    "Experimental Investigation of the Possibilities Open by Recent Sensitivity Improvements of Quadrupolar MQMAS Experiments"
  8. Thomas Vosegaard, Eigil Hald, Preben Daugaard, Hans J. Jakobsen,
    40th Experimental NMR Conference, Orlando, FL (February 1999).
    "Sensitivity Enhancement in Single-Crystal NMR Spectroscopy"
  9. Thomas Vosegaard, Ulf Andersen, Inger P. Byriel, Hans J. Jakobsen,
    39th Experimental NMR Conference, Asilomar, CA (April 1998).
    "Acquisition and Analysis of Complex Single-Crystal NMR Spectra"
  10. Thomas Vosegaard, Flemming H. Larsen, P. D. Ellis, Hans J. Jakobsen, Niels Chr. Nielsen,
    38th Experimental NMR Conference, Orlando, FL (February 1997).
    "Sensitivity-Enhanced MQ-MAS NMR of Quadrupolar Nuclei"
  11. Thomas Vosegaard, Jørgen Skibsted, Henrik Bildsøe, Hans J. Jakobsen,
    13th European Experimental NMR Conference, Paris (May 1996).
    "Quadrupole Coupling and Anisotropic Shielding from Single-Crystal NMR of the Central Transition for Quadrupolar Nuclei Employing a New Goniometer Design"

Lecture Notes

  1. Thomas Vosegaard,
    Class in Physical Biochemistry (November 2002).
    "Magnetic Resonance Imaging"