Department of Terrestrial Ecology|
National Environmental Research Institute
Vejlsoevej 25, P.O. Box 314
+45 8920 1481
Metabonomics is defined as the 'The quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification'. The metabonomic approach, therefore allows for an evaluation of the changes in metabolic profile of animals/humans exposed to changing environmental conditions, drugs, stress etc.
A number of experimental techniques can be used to measure the metabolic 'finger-print' of a biological sample. Here we primarily work with NMR-spectroscopy as this technique provides for quick measurements of a wide range of the metabolites found in a tissue sample.
We are currently working on the stress response in fruit-fly (Drosophilla melanogaster), where we in collaboration with other groups at the University of Aarhus are examining both changes in gene-expression and metabolic profile in response to physical stress such as heat, cold, starvation and longevity. In terms of metabonomics our aim is to identify how the multivariate metabolic pattern changes following a stress exposure. Through this approach we hope to identify key-metabolites and metabolic pathways that are affected by severe stress.
|Date of Birth:||Dec 30, 1971|
|Marital status:||Married, two children|
|1993-2000:||M.Sc. in Biology|
|2000-2003:||Ph.D. at Department of Zoophysiology, University of Aarhus.|
|2003-2005:||Post Doc. at ACES (Aarhus Center for Environmental Stress Research)|
|2004:||4-month position at POCEFF (EU-project concerning the use of copepod larvea as food source during commercial rearing of fish fry)|
Publications in Reviewed Journals
- Overgaard, J., Wang, T., Nielsen, O. B. and Gesser, H., Physiological and Biochemical Zoology , (In press).
Extracellular determinants of cardiac contractility in the cold, anoxic turtle.
- J. Ø. Hansen, C. Kehlet, M. Bjerring, T. Vosegaard, S. J. Glaser, N. Khaneja, and N. C. Nielsen, Chem. Phys. Lett. 447, 154-161 (2007).
Optimal control based design of composite dipolar recoupling experiments by analogy to single-spin inversion pulses
- J. Sørensen, H. F. Clausen, R. D. Poulsen, J. Overgaard, B. Schiøtt, and , J. Phys. Chem. 111, 345-351 (2007).
Short strong hydrogen bonds in 2-acetyl-1,8-dihydroxy-3,6-naphtalene – An outlier to
current hydrogen bonding theory?
- A. Malmendal, J. Overgaard, J. G. Bundy, J. G. S?rensen, N. C. Nielsen, V.
Loeschcke, and M. Holmstrup, American Journal of Physiology 291, 205-212 (2006).
Metabolomic Profiling of Heat Stress: Hardening and Recovery of Homeostasis in Drosophila
- Stecyk, J.A.W., Overgaard, J., Farrell, A.P. and Wang, T., Journal of Experimental Biology 207, 269-283 (2004).
Adrenergic regulation of systemic peripheral resistance and blood flow distribution in the turtle Trachemys scripta during anoxic submergence at 5?C and 21?C
- Overgaard, J., Stecyk, J. A. W., Gesser, H., Wang, T. and Farrell, A. P., Journal of Experimental Biology 207, 655-665 (2004).
Effects of temperature and anoxia upon the performance of in situ perfused trout hearts
- Overgaard, J., Stecyk, J.A.W., Gesser, H., Wang, T., Gamperl, A.K., and Farrell, A.P., Journal of Comparative Physiology B 174, 329-340 (2004).
Preconditioning stimuli do not benefit the myocardium of hypoxia-tolerant rainbow trout (Oncorhynchus mykiss)
- Overgaard, J. and Gesser, H., Journal of Experimental Biology 207, 1915-1924 (2004).
Force development, energy state and ATP production of cardiac muscle from turtles and trout during normoxia and severe hypoxia
- Wang T., Zaar M., Arvedsen S., Vedel-Smith C., Overgaard J., Comparative Biochemistry and Physiology 133A, 519-527 (2003).
Effects of temperature on the metabolic response to feeding in Python molurus
- Overgaard J., Andersen J.B. and Wang T., Physiological and Biochemical Zoology 75, 360-368 (2002).
The effects of fasting duration on the metabolic response to feeding in Python: An evaluation of the energetic costs associated with gastrointestinal growth and upregulation
- Overgaard J. and Wang T., Journal of Experimental Biology 205, 3327-3334 (2002).
Increased blood oxygen affinity during digestion in the snake Python molurus
- Overgaard J., Stecyk J.A.W., Farrell A.P., and Wang T., Journal of Experimental Biology 205, 3335-3345 (2002).
Adrenergic control of the cardiovascular system in the turtle Trachemys scripta
- Wang T., Busk M and Overgaard J. , Comparative Biochemistry and Phy 128A, 535-549 (2001).
The respiratory consequences of feeding in amphibians and reptiles
- Busk M., Overgaard J., Hicks J. W., Bennett A. F., and Wang T., Journal of Experimental Biology 203, 3117-3124 (2000).
Effects of feeding on arterial blood gases in the American alligator Alligator mississippiensis
- Overgaard J., Busk M., Hicks J. W., Jensen F. B. and Wang T., Comparative Biochemistry and Phy 124A, 359-365 (1999).
Respiratory consequences of feeding in the snake Python molurus
Centre for Respiratory Adaptation: 3rd Minisymposium, University of Odense (1998).
20th ESCPB Conference: Molecular, physiological and behavioural adaptations to environmental factors, University of Aarhus (1999).
Experimental Biology 2000 - Milestones and goals, University of Cambridge (2000).
Centre for Respiratory Adaptation: Last Minisymposium, University of Aarhus (2001).
International Workshop on Physiological Adaptations to Feeding and Digestion in Python, University of Aarhus (2001).
Society for Experimental Biology: Annual meeting, University of Kent at Canterbury (2001).
The 3rd Nordic Symposium on Fish, Frog and Reptile Physiology, Sweden (2002).
Society for Experimental Biology: Annual meeting, Heriot-Watt University, Edingborough (2004).
NorFA/GESS, Nordic network in environmental stress research, Ronbjerg, Denmark (2004).