This page is printed on Sep 26, 2017 from http://www.bionmr.chem.au.dk/bionmr/group/anders/index.php

 
 

 
Name:Anders Malmendal
Profession:Associate Professor
Email:anders@chem.au.dk
Homepage:None
Work address: Laboratory for Biomolecular NMR Spectroscopy
Department of Chemistry
University of Aarhus
Langelandsgade 140, DK-8000 Aarhus C, Denmark
Home address: Kaserneboulevarden 15 1. th
DK-8000 Aarhus C
Denmark
Office: Room 511-224
Office phone: +45 8942 3857
Dept. duties:

Research

NMR as a tool in complex biological systems. Development and application of NMR spectroscopy to metabolomic studies, and to the study of molecular structure and dynamics in chemistry, molecular biology, and nanotechnology. Exploration of metabolomic responses of a wide variety of systems. Determination of high-resolution three-dimensional structures and dynamics on various timescales for biological macromolecules, drugs, organic compounds using liquid- and solid-state NMR, with focus on insoluble systems such as fibrillating proteins, membrane proteins. Major areas include coupling of metabolomic responses to different stimuli and other omic responses; coupling of protein dynamics and structure and their response to interactions with ions, other proteins, membranes, etc, with a special focus on protein folding and misfolding.
 

Curriculum Vitae


Personal data

Name:Anders Malmendal
Nationality:Swedish
Date of Birth:January 13, 1967


Education

1993:M. Sc., Chemical Engineering, Lund University and ENSIGC Toulouse
1999:Ph. D., Physical Chemistry, Lund University


Appointments

1993 - 1999:Ph.D. training position, Physical Chemistry 2, Lund University, Lund, Sweden
1999:STINT (The Swedish Foundation for International Cooperation in Research and Higher Education) postdoctoral fellow, Dept. Mol. Biol. & Dept. Cell. Biol., Scripps Research Institute, La Jolla, CA, USA
1999 - 2001:STINT postdoctoral fellow, Dept. Biochem., Vanderbilt University Medical Center, Nashville, TN, USA
2001 - 2005:Research Assistant Professor, Laboratory for Biomolecular NMR Spectroscopy, Dept. Mol. Biol. & Dept. Chem., University of Aarhus, Aarhus, Denmark
2005 -:Research Associate Professor, Laboratory for Biomolecular NMR Spectroscopy, Dept. Chem., University of Aarhus, Aarhus, Denmark

Publications

Publications in Reviewed Journals

  1. P. Sarum, S.M.M. Pedersen, N.C. Nielsen, A. Malmendal, and V. Loeschcke, PloS ONE 7, e47461 (2012).
    The Metabolic Profile of Long-Lived Drosophila melanogaster
  2. A. Calcutta, C. M. Jessen, M. A. Behrens, C. L. P. Oliveira, M. L. Renart, J. M. Gonzalez-Ros, D. E. Otzen, J. S. Pedersen, A. Malmendal, and N. C. Nielsen, BBA Biomembranes 1818, 2290-2301 (2012).
    Mapping of Unfolding States of Integral Helical Membrane Proteins by GPS-NMR and Scattering Techniques: TFE-Induced Unfolding of KcsA in DDM Surfactant
  3. S. Slotsbo, L.M. Hansen, K. Jordaens, A. Malmendal, N.C. Nielsen, M. Holmstrup, Comp. Biochem. Physiol. 161, 443-449 (2012).
    Cold Tolerance and Freeze-Induced Accumulation in Three Terrestrial Slugs
  4. S.M.M. Pedersen, C. Nebel, N.C. Nielsen, H.J. Andersen, J. Olsson, M. Simrén, L. Ôhrman, U. Svensson, H.C. Bertram, and A. Malmendal, Eur. Food Res. Technol. 233, 1013-1021 (2011).
    A GC-MS Based Metabonomics Investigation of Blood Serum from Irritable Bowel Syndrome Patients Undergoing Intervention with Acidified Milk Products
  5. L. Jiang, A.S.P. Svane, H.P. Sørensen, J.K. Jensen, M. Hosseini, Z. Chen, C. Weydert, J.T. Nielsen, A. Christensen, C. Yuana, K.J. Jensen, N.C. Nielsen, A. Malmendal, M. Huang, and P.A. Andreasen, J. Mol. Biol. 412, 335-350 (2011).
    The Binding Mechanism of a Peptidylic Cyclic Serine Protease Inhibitor
  6. D. Waagner, L.-H. Heckmann, A. Malmendal, N.C. Nielsen, M. Holmstrup, and M. Bayley, Comparative Biochemistry and Phy 157, 177-183 (2010).
    Hsp70 expression and metabolite composition in response to short-term thermal changes in Folsomia candida
  7. M. Bayley, J. Overgaard, A. S. Høj, A. Malmendal, N. C. Nielsen, M. Holmstrup, and T. Wang, Phys. Biochem. Zool 83, 541-550 (2010).
    Metabonomic Changes During Aestivation in the Common Earthworm Aporrectodea caliginosa
  8. A. Malmendal, J. Underhaug, D.E. Otzen, and N.C. Nielsen, PloS ONE 5, e10626 1-e10626 6 (2010).
    Fast Mapping of Global Protein Folding States by Multivariate NMR: A GPS for Proteins
  9. J. F. Young, L. B. Larsen, A. Malmendal, N. C. Nielsen, I. K. Straadt, N. Oksbjerg, and H. C. Bertram, Journal of the International Society of Sports Nutrition 7:9, 1-10 (2010).
    Creatine-induced activation of antioxidative defence in myotube cultures revealed by explorative NMR-based metabonomics and proteomics
  10. H. C. Bertram, A. Malmendal, N. C. Nielsen, I. K. Straadt, T. Larsen, K. E. B. Knudsen, and H. N. Lærke, Mol. Nutrition Food Res 53, 1055-1062 (2009).
    NMR-based metabonomics reveals that betaine plasma betaine increases upon intake of high-fiber rye buns in hypercholesterolaemic pigs
  11. H. C. Bertram, N. B. Kristensen, M. Vestergaard, S. K. Jensen, J. Sehested, N. C. Nielsen, and A. Malmendal, Livestock Science 120, 127-134 (2009).
    Metabolic Characterization of Rumen Epithelial Tissue from Dairy Calves Fed Different Starter Diets using 1H NMR Spectroscopy
  12. R. Halaban, M. Krauthammer, M. Pelizzola, E. Cheng, D. Kovacs, M. Sznol, S. Ariyan, D. Narayan, A. Bacchiocchi, A. Molinaro, Y. Kluger, M. Deng, N. Tran, W. Zhang, M. Picardo, and J. J. Enghild, PLoS ONE 4, e4563 (2009).
    Integrative analysis of epigenetic modulation in melanoma cell response to decitabine: clinical implications
  13. S. Slotsbo, K. Maraldo, A. Malmendal, N. C. Nielsen, and M. Holmstrup, Cryobiology 57, 286-291 (2008).
    Freeze-tolerance and accumulation of cryoprotectants in the enchytraied Enchytraeus albidus (Oligochaeta) from Greenland and Europe
  14. K. E. Nielsen, J. Dittmer, A. Malmendal, and N. C. Nielsen, Energy & Fuels 22, 4070-4076 (2008).
    Quantitative analysis of constituents in heavy fuel oil by 1H Nuclear Magnetic Resonance (NMR) spectroscopy and multivariate data analysis
  15. K. S. Pedersen, T. N. Kristensen, V. Loeschcke, B. O. Pedersen, J. Ø. Duus, N. C. Nielsen and A. Malmendal, Genetics 180, 1233-1243 (2008).
  16. J. Overgaard, A. Malmendal, J. G. S?rensen, J. G. Bundy, V. Loeschcke, N. C. Nielsen, and M. Holmstrup, J. Insect Physiol 53, 1218-1232 (2007).
    Metabolomic profiling of rapid cold hardening and cold shock in Drosophila melanogaster
  17. J. F. Young, H. C. Bertram, P. K. Theil, A.-G. D. Petersen, K. A. Poulsen, M. Rasmussen, A. Malmendal, N. C. Nielsen, M. Vestergaard, and N. Oksbjerg, Meat Science 76, 342-351 (2007).
    In vitro and in vivo studies of creatine monohydrate supplementation to Duroc and Landrace pigs
  18. J. K. Jensen, A. Malmendal, B. Schi?tt, S. Skeldal, K. E. Petersen, L. Celik, N. C. Nielsen, P. A. Andreasen, and T. Wind, Biochemical Journal 399, 387-396 (2006).
    Inhibition of Plasminogen Activator Inhibitor-1 Binding to Endocytosis Receptors of the low Density Lipoprotein Receptor Family by a Peptide Isolated from a Phage Displayed Library
  19. J. Underhaug, L. Odgaard Jakobsen, A. Malmendal, P. Fojan, M. Esmann, and N. C. Nielsen, FEBS Lett. 580, 4777-4783 (2006).
    NMR studies of the Fifth Transmembrane Segment of Na+,K+-ATPase Reveals a Non-Helical Ion-Binding Region
  20. A. Malmendal, J. Overgaard, J. G. Bundy, J. G. S?rensen, N. C. Nielsen, V. Loeschcke, M. Holmstrup, American Journal of Physiology 291, 205-212 (2006).
    Metabolomic Profiling of Heat Stress: Hardening and Recovery of Homeostasis in Drosophila
  21. H.C. Bertram, K.E.B. Knudsen, A. Serana, A. Malmendal, N.C. Nielsen, X.C. Frett? and H.J. Andersen, British J. Nutrition 5, 955-962 (2006).
    NMR-based Metabonomic Studies Reveal Changes in the Biochemical Profile of Plasma and Urine from Pigs Fed High Fiber a Rye Bread
  22. H. C. Bertram, N. B. Kristensen, A. Malmendal, N. C. Nielsen, R. Bro, H. J. Andersen, and D. L. Harmon, Analytica Chimica Acta 536, 1-6 (2005).
    A metabolomic investigation of splanchnic metabolism using 1H NMR spectroscopy of bovine blood plasma
  23. A. Malmendal, C. W. Vander Kooi, N. C. Nielsen, and W. Chazin, Biochemistry 44, 6502-6512 (2005).
    Calcium-modulated S100 protein-phospholipic interactions. An NMR study of calbindin D9k and DPC
  24. N.C. Nielsen, A. Malmendal, and T. Vosegaard, Mol. Membr. Biol. 21, 129-141 (2004).
    Techniques and Applications of NMR to Membrane Proteins
  25. H.C. Bertram, N.B. Kristensen, A. Malmendal, N.C. Nielsen, S.K. Jensen, and D.L. Harnon, J. Anum Feed. Sci. , 295-298 (2004).
    An NMR-based metabolomic approach to assess metabolism in splanchnic tissues of steers
  26. J. Christodoulou, A. Malmendal, J.F. Harper, W.J. Chazin., J. Biol. Chem. 279, 29092-29100 (2004).
    Evidence for differing roles for each lobe of the Calmodulin-like domain in a calcium-dependent protein kinase (CDPK)
  27. M. Bjerring, T. Vosegaard, A. Malmendal, and N. C. Nielsen, Concepts Magn. Reson. 18A, 111-129 (2003).
    Methodological Development of Solid-State NMR for Characterization of Membrane Proteins
  28. G. Nielsen, A. Malmendal, A. Meissner, J. Vuust Møller, and N. C. Nielsen, FEBS Lett. 544, 50-56 (2003).
    NMR studies of the fifth transmembrane segment of sarcoplasmic reticulum Ca2+-ATPase reveals a hinge close to the Ca2+ ligating residues
  29. A. Malmendal, S. Halpain, and W. J. Chazin, Biochem. Biophys. Res. Comm. 301, 136-142 (2003).
    Nascent structure in the kinase anchoring domain of microtubule-associated protein 2.
  30. T. Vosegaard, A. Malmendal, and N. C. Nielsen, Chem. Monthly 133, 1555-1574 (2002).
    The Flexibility of SIMPSON and SIMMOL for Numerical Simulations in Solid and Liquid-State NMR Spectroscopy
  31. J. Evenäs, A. Malmendal, and M. Akke, Structure 9, 185-195 (2001).
    Dynamics of the Transition between Open and Closed Conformations in a Calmodulin C-Terminal Domain Mutant
  32. A. Malmendal, S. Linse, J. Evenäs, S. Forsén, and T. Drakenberg, Biochemistry 38, 11844-11850 (1999).
    Battle for the EF-Hands: Magnesium-Calcium Interference in Calmodulin
  33. J. Evenäs, S. Forsén, A. Malmendal, and M. Akke, J. Mol. Biol. 289, 603-617 (1999).
    Backbone Dynamics and Energetics of a Calmodulin Domain Mutant Exchanging between Closed and Open Conformations
  34. A. Malmendal, J. Evenäs, S. Fors'en, and M. Akke, J. Mol. Biol. 293, 883-899 (1999).
    Structural Dynamics in the C-terminal Domain of Calmodulin at Low Calcium Levels
  35. A. Malmendal, G. Carlström, C. Hambraeus, T. Drakenberg, S. Forsén, and M. Akke, Biochemistry 37, 2586-2595 (1998).
    Sequence and Context Dependence of EF-Hand Loop Dynamics. An 15N Relaxation Study of a Calcium-Binding Site Mutant of Calbindin D9k
  36. J. Evenäs, A. Malmendal, and S. Forsén, Curr. Opin. Chem. Biol. 2, 293-302 (1998).
    Calcium
  37. J. Evenäs, A. Malmendal, E. Thulin, G. Carlström, and S. Forsén, Biochemistry 37, 13744-13754 (1998).
    Ca2+ Binding and Conformational Changes in a Calmodulin Domain
  38. A. Malmendal, J. Evenäs, E. Thulin, G. P. Gippert, T. Drakenberg, and S. Forsén, J. Biol. Chem. 273, 28994-29001 (1998).
    When Size Is Important: Accomodation of magnesium in a calcium binding regulatory domain
  39. M. Andersson, A. Malmendal, S. Linse, I. Ivarsson, S. Forsén, and L. A. Svensson, Protein Sci. 6, 1139-1147 (1997).
    Structural basis for the negative allostery between Ca2+- and Mg2+-binding in the intracellular Ca2+-receptor calbindin D9k
  40. J. Evenäs, E. Thulin, A. Malmendal, S. Forsén, and G. Carlström, Biochemistry 36, 3448-3457 (1997).
    NMR Studies of the E140Q Mutant of the Carboxy-Terminal Domain of Calmodulin Reveal Global Conformational Exchange in the Ca2+-Saturated State
  41. D. Bentrop, I. Bertini, M. A. Cremonini, S. Forsén, C. Luchinat, and A. Malmendal, Biochemistry 36, 11605-11618 (1997).
    Solution Structure of the Paramagnetic Complex of the N-Terminal Domain of Calmodulin with Two Ce3+ Ions by 1H NMR